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mavacamten will minimize the level or result of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten could lower systemic exposures of ethinyl estradiol and progestin, which may bring on contraceptive failure or an increase in brea